Table 1 Characteristics of the ROSMAP cohort
DLPFC (n = 454) | PCC (n = 66) | CB (n = 242) | |
|---|---|---|---|
Sex (male) | 158 (34.8%) | 21 (31.8%) | 71 (29.3%) |
Age (years) | 89.3 (6.6) | 89.1 (5.6) | 88 (6.7) |
Pathologic AD | 308 (67.8%) | 45 (68.2%) | 141 (58.3%) |
Amyloid (% area affected) | 4.6 (4.4) | 3.9 (3.8) | 4 (4.3) |
Tau (% area affected) | 7.4 (8.1) | 6.8 (6.8) | 6.2 (7.9) |
TDP-43 (none, amygdala, limbic, neocortical) | 205, 76, 97, 44 (48.6, 18.0, 23.0, 10.4%) | 23, 16, 12, 12 (36.5, 25.4, 19.0, 19.0%) | 96, 45, 38, 33 (45.3, 21.2, 17.9, 15.6%) |
Lewy bodies (none, nigral, limbic, neocortical) | 337, 7, 32, 60 (77.3, 1.6, 7.3, 13.8%) | 48, 2, 2, 9 (78.7, 3.3, 3.3, 14.8%) | 184, 6, 21, 25 (78.0, 2.5, 8.9, 10.6%) |
Cerebral amyloid angiopathy (none, mild, moderate, severe) | 92, 191, 110, 52 (20.7, 42.9, 24.7, 11.7%) | 13, 25, 16, 11 (20.0, 38.5, 24.6, 16.9%) | 58, 101, 51, 24 (24.8, 43.2, 21.8, 10.3%) |
Cerebral atherosclerosis (none, mild, moderate, severe) | 84, 212, 123, 33 (18.6, 46.9, 27.2, 7.3%) | 11, 25, 19, 11 (16.7, 37.9, 28.8, 16.7%) | 39, 114, 72, 15 (16.2, 47.5, 30.0, 6.2%) |
Arteriolosclerosis (none, mild, moderate, severe) | 136, 157, 118, 42 (30.0, 34.7, 26.0, 9.3%) | 9, 26, 22, 9 (13.6, 39.4, 33.3, 13.6%) | 78, 79, 65, 17 (32.6, 33.1, 27.2, 7.1%) |
Gross chronic infarcts (one or more) | 171 (37.7%) | 22 (33.3%) | 83 (34.3%) |
Chronic microinfarcts (one or more) | 132 (29.1%) | 18 (27.3%) | 70 (28.9%) |
Hippocampal sclerosis (present) | 39 (8.7%) | 6 (9.2%) | 22 (9.2%) |
Post mortem interval (hours) | 8.4 (5.7) | 6.6 (4.7) | 8.3 (6.7) |