Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer’s disease brain

Table 2 Effect of APOE ε4 genotype on mtDNAcn

Region/Study	N of APOE ε4 dosages (0, 1, 2)	Unadjusted for pathology			Adjusted for pathology*
Region/Study	N of APOE ε4 dosages (0, 1, 2)	β	SE	p	β	SE	p
DLPFC/ROSMAP	335, 112, 7	−0.364	0.099	2.8 × 10^− 04	−0.204	0.105	0.051
CB/ROSMAP	182, 56, 4	−0.292	0.134	0.031	−0.223	0.144	0.124
TCX/Mayo	183, 70, 9	−0.280	0.114	0.015	−0.126	0.121	0.301
FP/MSBB	171, 88, 11	−0.158	0.106	0.137	−0.048	0.104	0.642
Meta-analysis	871, 326, 31	−0.275	0.056	8.0 × 10^− 07	−0.141	0.058	0.014

*ROSMAP was adjusted by adding a quantitative score for amyloid and tau burden to the model. Mayo and MSBB were adjusted by adding the pathologic diagnosis to the model

ISSN: 1750-1326