From: The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives
siRNA | miRNA | |
---|---|---|
Structure | Double-stranded RNA duplex, 2 nucleotides 3'-overhang | Double-stranded RNA duplex, 2 nucleotides 3'-overhang |
Target complementarity | Fully complementary to mRNA target | Partial and imperfect complementarity |
mRNA targets | One specific target | Multiple context-specific targets |
Mechanism of action | mRNA cleavage by endonucleolytic capacity | mRNA cleavage |
mRNA decay | ||
Translational repression | ||
Clinical application | Therapeutic agent to knockdown specific mRNA target | Drug target (miRNA mimics & inhibitors) |
Therapeutic agent for the regulation of multiple mRNA targets (miRNA inhibitors) | ||
Diagnostic tool (biomarkers) |