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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans

Fig. 6

Acetaminophen, caffeine, losartan, rapamycin, and rifabutin reduce coiling due to α-synuclein-mediated dopaminergic neuron dysfunction in vivo. (a) Coiler scores of syn animals and GFP animals treated with vehicle or 100 μM of drug, normalized to vehicle treated control GFP animals (N = 12 populations of n = 10 animals per treatment group) (one-way ANOVA with Tukey’s post-hoc test, **p < 0.01, ***p < 0.001, ****p < 0.0001). (b) Locomotory speed of syn animals treated with vehicle or 100 μM of drug, normalized to vehicle treated control GFP animals (N = 12 populations of n = 10 animals per treatment group, two-tailed t-test, *p < 0.05). (c) No statistically significant changes in coiler scores of unc-10(e102) animals treated with vehicle or 100 μM of drug, normalized to vehicle treated unc-10(e102) animals (N = 12 populations of n = 10 animals per treatment group) (one-way ANOVA with Tukey’s post-hoc test). Each data point represents an individual population

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