Table 1 Full mature sequences, previously reported TLR-activating sequences (bold), and minimum free energy of selected miRNAs detected extracellularly enriched (Log2 Fold Changes; P values) upon neuronal apoptosis induction compared to control condition, as assessed by miRNA array
miRNA | Mature sequence | Log2 Fold Change | P value | Minimum free energy [kcal/mol] |
|---|---|---|---|---|
miR-151-5p | UCGAGGAGCUCACAGUCUAGU | 5.28 | 9.60E-08 | −0.6 |
miR-672-5p | UGAGGUUGGUGUACUGUGUGUGA | 4.83 | 5.94E-07 | 0 |
miR-674-5p | GCACUGAGAUGGGAGUGGUGUA | 4.6 | 6.98E-06 | −3.8 |
miR-361-5p | UUAUCAGAAUCUCCAGGGGUAC | 4.47 | 0.007266 | −0.1 |
let-7 g-5p | UGAGGUAGUAGUUUGUACAGUU | 4.46 | 2.84E-05 | −0.5 |
miR-652-3p | AAUGGCGCCACUAGGGUUGUG | 4.29 | 2.28E-06 | −3.4 |
miR-342-5p | AGGGGUGCUAUCUGUGAUUGAG | 4.28 | 4.39E-06 | 0 |
miR-100-5p | AACCCGUAGAUCCGAACUUGUG | 4.11 | 6.98E-05 | 0 |
miR-7020-5p | UGGGAUGGUGGAGAGGGUGACCAG | 4.03 | 1.29E-07 | −2.9 |
miR-128-3p | UCACAGUGAACCGGUCUCUUU | 3.95 | 0.007777 | 0 |
miR-298-5p | GGCAGAGGAGGGCUGUUCUUCCC | 3.55 | 2.28E-06 | −5.5 |
miR-501-3p | AAUGCACCCGGGCAAGGAUUUG | 3.65 | 4.60E-06 | − 1.8 |