Fig. 2

PMC vs NC. A PCA based on four proteins (GRN, KNG1, AQP4 and UPF0606 protein KIAA1549L) selected by either LASSO or Random forest when all PMC (n = 98, green triangles) and NC (n = 76, blue dots) were included. B PCA based on six proteins (GRN, TARDBP, KNG1, HBEGF, MBP and CLSTN1) selected by either LASSO or Random forest when the selection was based on age and pathology filtered individuals (NC n = 34 blue dots, PMC C9orf72 n = 13 red triangles, PMC GRN n = 22 orange squares). C One protein was selected by both LASSO and Random forest: GRN, presented with p-values from Wilcoxon rank sum test. Same number of individuals included as in B. NC, non-carriers; C9orf72, chromosome 9 open reading frame 72; GRN, progranulin; AU, arbitrary units