|  | Total | Affected mutation carriers | Presymptomatic mutation carriers | Non-carriers | p-value |
---|---|---|---|---|---|---|
Number of individuals | 221 | 47 | 98 | 76 | – | |
Sex distribution [F/M] | 119/102 | 20/27 | 58/40 | 41/35 | 0.17a | |
Age [mean ± SD (range)] | 50 ± 14 (20–76) | 62 ± 9 (38–76) | 46 ± 12 (20–74) | 47 ± 13 (20–69) | 3e-14b | |
Age at onset [mean ± SD (range)] |  | 58 ± 9 (35–73) |  |  | – | |
Mutation [N (%)] | C9orf72 | Â | 27 (57) | 41 (42) | Â | Â |
GRN | Â | 12 (26) | 38 (39) | Â | Â | |
MAPT | Â | 7 (15) | 16 (16) | Â | Â | |
TBK1 | Â | 1 (2) | 3 (3) | Â | Â | |
Clinical phenotype [N (%)] | bvFTD | Â | 32 (68) | Â | Â | Â |
PPA | Â | 7 (15) | Â | Â | Â | |
Otherc | Â | 8 (17) | Â | Â | Â |