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Table 2 Proteins selected from LASSO or random forest when comparing affected and unaffected individuals

From: A panel of CSF proteins separates genetic frontotemporal dementia from presymptomatic mutation carriers: a GENFI study

Protein Description Uniprot Antibody LASSO
% selected
Random forest
Mean mda
NEFM* Neurofilament medium polypeptide P07197 HPA022845 100 28.1
NPTX2* Neuronal pentraxin 2 P47972 HPA049799 71.6 8.4
VGF* Neurosecretory protein VGF O15240 HPA055177 40.2 9.2
AQP4* Aquaporin 4 P55087 HPA014784 26.5 11.3
APOE4 Apolipoprotein E isoform 4 Q8TCZ8 M067–3 55.6 0.8
SEC63 Translocation protein SEC63 homolog Q9UGP8 HPA053295 40.2 3.1
APOA1 Apolipoprotein A1 P02647 HPA046715 31.5 4.2
PTPRN2 Protein tyrosine phosphatase, receptor type N2 Q92932 HPA007255 8.8 8.2
CTSS Cathepsin S P25774 HPA002988 7.6 9.4
SERPINA3 Serpin family A member 3 P01011 HPA000893 0 12.8
C4A/B Complement C4A, complement C4B P0C0L4, P0C0L5 HPA046356 0 11.0
AMPH Amphiphysin P49418 HPA019829 0 9.5
SPP1 Secreted phosphoprotein 1 P10451 NBP2–37423 0 8.8
CD14 Monocyte differentiation antigen CD14 P08571 HPA002035 0 8.5
  1. Asterisk next to the protein name show which proteins were selected by both LASSO and Random forest. Proteins with grey numbers in the LASSO or Random forest columns did not meet the selected cut-off for that model. LASSO indicates in how many models a protein was selected (% out of 1000 models). Random forest indicates the mean mda from 1000 models