A panel of CSF proteins separates genetic frontotemporal dementia from presymptomatic mutation carriers: a GENFI study

Table 2 Proteins selected from LASSO or random forest when comparing affected and unaffected individuals

Protein	Description	Uniprot	Antibody	LASSO % selected	Random forest Mean mda
NEFM*	Neurofilament medium polypeptide	P07197	HPA022845	100	28.1
NPTX2*	Neuronal pentraxin 2	P47972	HPA049799	71.6	8.4
VGF*	Neurosecretory protein VGF	O15240	HPA055177	40.2	9.2
AQP4*	Aquaporin 4	P55087	HPA014784	26.5	11.3
APOE4	Apolipoprotein E isoform 4	Q8TCZ8	M067–3	55.6	0.8
SEC63	Translocation protein SEC63 homolog	Q9UGP8	HPA053295	40.2	3.1
APOA1	Apolipoprotein A1	P02647	HPA046715	31.5	4.2
PTPRN2	Protein tyrosine phosphatase, receptor type N2	Q92932	HPA007255	8.8	8.2
CTSS	Cathepsin S	P25774	HPA002988	7.6	9.4
SERPINA3	Serpin family A member 3	P01011	HPA000893	0	12.8
C4A/B	Complement C4A, complement C4B	P0C0L4, P0C0L5	HPA046356	0	11.0
AMPH	Amphiphysin	P49418	HPA019829	0	9.5
SPP1	Secreted phosphoprotein 1	P10451	NBP2–37423	0	8.8
CD14	Monocyte differentiation antigen CD14	P08571	HPA002035	0	8.5

Asterisk next to the protein name show which proteins were selected by both LASSO and Random forest. Proteins with grey numbers in the LASSO or Random forest columns did not meet the selected cut-off for that model. LASSO indicates in how many models a protein was selected (% out of 1000 models). Random forest indicates the mean mda from 1000 models

ISSN: 1750-1326