A panel of CSF proteins separates genetic frontotemporal dementia from presymptomatic mutation carriers: a GENFI study

Table 3 Proteins selected when comparing age and pathology filtered PMC to NC

Protein	Description	Uniprot	Antibody	LASSO % selected	Random forest Mean mda
GRN*	Progranulin	P28799	AF2420	99.9	23.4
TARDBP	TAR DNA binding protein 43	Q13148	HPA070770	85.8	−0.1
KNG1	Kininogen 1	P01042	HPA001645	82.2	1.6
HBEGF	Heparin binding EGF like growth factor	Q99075	HPA053243	82.2	1.5
MBP	Myelin basic protein	P02686	HPA049222	0	5.0
CLSTN1	Calsyntenin-1	O94985	HPA012749	0	5.0

Selection from LASSO and Random forest when comparing PMC (n = 35) and NC (n = 34) (age and pathology filtered). Only GRN was selected by both LASSO and Random forest. Proteins with grey numbers in LASSO or Random forest columns did not meet the cut-off for that model. LASSO indicates in how many models a protein was selected (% out of 1000 models). Random forest indicates the mean mda from 1000 models

ISSN: 1750-1326