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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice

Fig. 6

MVC prevented HIV-induced downregulation of the neurofilament-L (NFL). a: immunofluorescence analyses of NFL expression in brain tissues. b: densitometry quantification of NFL expression in all samples (somatosensory cortex, 10 random FOV analyzed for each sample). NFL levels in animals’ brain tissues were also quantified by Western blot analyses (c) followed by densitometry quantification normalized to sample’s β-actin levels (d). e: Real-time PCR quantification of NFL mRNA in brain tissues. For panel a, images were at 40X. The four animal groups included PBS, HIV, HIV + MVC and MVC; 9 to 11 animals in each group. #P < 0.0001, ***P < 0.0002, **P < 0.003. Error bars represent SD

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