Fig. 6
From: Neuropathology and molecular diagnosis of Synucleinopathies
Representative images of histopathology of MSA. A-D Hematoxylin and eosin staining. A Severe neuronal loss with gliosis in the lateral putamen. B Neurodegeneration is minimal in the same region in a case of minimal change MSA. C A typical MSA shows neuronal loss with extracellular neuromelanin pigment (arrows) in the substantia nigra, while it is well preserved in minimal change MSA (D). E-J Immunohistochemistry for α-synuclein (NACP antibody). Numerous GCIs in the putamen (E) and substantia nigra (F). Arrows indicate extracellular neuromelanin pigment (F). Neuronal cytoplasmic inclusions in the pontine nucleus (G, arrows) and inferior olivary nucleus (H, arrow). Abundant neuronal cytoplasmic inclusions in the dentate fascia in FTLD-synuclein (I) and hippocampal MSA (J). Scale bars: 50 μm in all images