Table 2 Studies on α-synuclein RT-QuIC using CSF
From: Neuropathology and molecular diagnosis of Synucleinopathies
Author | Autopsy | Disease | N | N Control | Sensitivity | Specificity |
|---|---|---|---|---|---|---|
Fairfoul [237] | Yes | Pure DLB | 12 | 20 | 92% | 100% |
DLB with AD | 17 | 20 | 65% | 100% | ||
AD with ILBD | 13 | 20 | 15% | 100% | ||
PD | 2 | 20 | 100% | 100% | ||
No | PD | 20 | 15 | 95% | 100% | |
IRBD | 3 | 15 | 100% | 100% | ||
Manne [248] | No | PD | 15 | 11 | 94% | 100% |
Shahnawaz [238] | No | PD | 76 | 65 | 88% | 94% |
DLB | 10 | 65 | 100% | 94% | ||
MSA | 10 | 65 | 80% | 94% | ||
Groveman [239] | Yes | PD | 12 | 31 | 92% | 100% |
DLB | 17 | 32 | 94% | 100% | ||
Bongianni [240] | Yes | DLB | 7 | 49 | 100% | 96% |
MSA | 1 | 50 | 100% | 96% | ||
Mixed LBD *2 | 20 | 51 | 90% | 96% | ||
No | DLB | 26 | 10 | 65% | 100% | |
Kang [241] | No | PD | 105 | 79 | 96% | 82% |
Van Rumund [242] | Yes *1 | PD | 53 | 52 | 84% | 98% |
MSA | 17 | 52 | 35% | 98% | ||
DLB | 1 | 52 | 100% | 98% | ||
Garrido [243] | No | PD | 10 | 10 | 90% | 80% |
LRRK2-PD | 15 | 10 | 40% | 80% | ||
LRRK2-NMC | 16 | 10 | 19% | 80% | ||
Rossi [244] | Yes | DLB | 14 | 101 | 100% | 98% |
Mixed LBD *3 | 7 | 102 | 86% | 98% | ||
No | DLB | 34 | 166 | 97% | 94% | |
PD | 71 | 167 | 94% | 94% | ||
IRBD | 18 | 168 | 100% | 94% | ||
PAF | 28 | 169 | 93% | 94% | ||
Iranzo [245] | No | IRBD | 52 | 40 | 90% | 90% |
Shahnawaz [246] | No | PD | 94 | 56 | 94% | 100% |
MSA | 75 | 56 | 85% | 100% | ||
PD vs. MSA | 88 | 65 *4 | 97% | 94% | ||
Rossi [257] | No | MCI-LB | 81 | 58 | 95% | 97% |
Perra [249] | No | DLB | 16 | 32 | 100% | 90% |