Fig. 3

BL changes in aging and neurological disorders. Diagram illustrations showing changes of BL, endothelial cells, pericytes, microglia, neurons, and protein aggregates in aging and three neurodegenerative disorders (AD, PD, and ALS). BL: basal lamina; EC: endothelial cell; PC: pericytes; As: astrocytes; rM: resting microglia; pM: primed microglia; aM: activated microglia; hN: healthy neurons; iN: injured neurons; Aβ: β-amyloid; α-Syn: α-synuclein; SC: serum components; AD: Alzheimer’s disease; PD: Parkinson’s disease; ALS: amyotrophic lateral sclerosis