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Table 2 Changes of the BL and its major components during normal aging

From: Basal lamina changes in neurodegenerative disorders

Normal Aging

Changes

References

BL

Rodents

Thickening

[207,208,209]

Humans

Thickening

[210,211,212]

Collagen IV

Rodents

↑

[209]

↓

[207]

↔

[66]

Humans

↑

[210, 211]

↔

[212]

Laminin

Rodents

↑

[209]

↓

[66, 207]

Humans

↓

[211]

Nidogen

Rodents

↑

[209]

↓

[207]

Humans

↑

[212]

Agrin

Rodents

Unknown

Humans

↑

[211]

Perlecan

Rodents

↑

[66, 207, 209]

Humans

Unknown

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Molecular Neurodegeneration

ISSN: 1750-1326