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Table 3 Changes of the BL and its major components in AD

From: Basal lamina changes in neurodegenerative disorders

AD

Changes

Models

References

BL

Rodents

Thickening

3xTG, PSEN1P117L, APPswe/E693G

[231,232,233,234]

Humans

Thickening

-

[210, 212, 235,236,237,238,239,240,241,242]

Thinning

-

[243]

Collagen IV

Rodents

↑

3xTG

[232, 234]

↓

APPswe, APOE4

[244, 245]

↔

PSEN1P117L

[233]

Humans

↑

-

[210, 235, 237,238,239, 241, 246, 247]

↔

-

[212]

Laminin

Rodents

↑

APPswe/E693G

[231]

↓

APOE4

[244]

↔

PSEN1P117L

[233]

Humans

↑

-

[248, 249]

Nidogen

Rodents

Unknown

Humans

↓

-

[212]

Agrin

Rodents

↔

APOE4

[244]

Humans

↑

-

[235, 250]

↓

-

[243]

Perlecan

Rodents

↔

APOE4

[244]

Humans

↑

-

[235]