Table 5 Changes of the BL and its major components in ALS
ALS | Changes | Models | References | |
|---|---|---|---|---|
BL | Rodents | Thickening, duplication | SOD1G93A | [40] |
Humans | Exposed to plasma proteins | - | [48] | |
Collagen IV | Rodents | ↑ | SOD1G93A | [45] |
Humans | ↑ | - | [48] | |
↓ | - | |||
↔ | - | [339] | ||
Laminin | Rodents | ↓ | SOD1G93A | [41] |
Humans | ↑ | - | ||
↔ | - | [339] | ||
↓ | - | [342] | ||
Nidogen | Rodents | Unknown | ||
| Â | Humans | |||
Agrin | Rodents | ↓ | SOD1G93A | |
Humans | ↔ | - | [339] | |
Perlecan | Rodents | Unknown | ||
Humans | ||||