Sleep and circadian rhythms in Parkinson’s disease and preclinical models

Table 1 Summary of Findings

Disease Model	How comprehensive is the body of sleep/circadian research in this model?	Does this model reflect human PD-related circadian rhythm changes?	Does this model reflect human PD-related sleep dysfunction?	References
6-OHDA	***	++	+++	[18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36]
MPTP	***	--	---	[37,38,39,40,41,42,43,44,45,46]
Rotenone	**	+	+	[47,48,49,50,51,52,53]
α-Synuclein Transgenic	**	++	+++	[54,55,56,57,58,59]
LRRK-G2019S Transgenic	*	N/A	+	[60]
VMAT2-deficient	*	-	--	[61, 62]
MitoPark	*	+++	+++	[63, 64]
Cycad	*	+	N/A	[65]
Paraquat/Maneb	N/A	N/A	N/A	––––
PFF	N/A	N/A	N/A	––––
Other Transgenic models (i.e. DJ-1, PINK)	N/A	N/A	N/A	––––

Table 1: Evidence is indicated by – and +, with --- being compelling evidence for a lack of a PD-like phenotype, +++ being compelling evidence of a PD-like phenotype, comprehensiveness of the body of research indicated by asterisks, where *** is very comprehensive, ** requires further studies to corroborate and further confirm, * a very limited number of studies have been relied upon to arrive at the particular conclusion, N/A where no studies have been performed

ISSN: 1750-1326