Fig. 2

The co-expression patterns of the CellAge SnGs and SnG-enriched modules. a Heatmap plot of the clusters of the CellAge SnGs and SnG-enriched modules, with each row representing for a SnG and each column for a SnG-enriched module. The hierarchical dendrograms were shown for the heatmap and further split based on the k-means clusters (k = 4, 100 iterations). The red color of each pixel indicates the presence of a SnG in a module. The blue dotted rectangles indicate three representative gene-module clusters shown in panel 2b. b Heatmap plots of three representative gene-module clusters from sc4-mc4, sc3-mc3, and sc2-mc4, respectively. Each row represents a SnG, and each column represents a module in the selected cluster. c-d The consensus networks of CDKN1A (c) and TP53 (d) neighborhood genes across 50 tissues. The network of each gene was constructed by aggregating 3-layer neighbor genes across 50 co-expression networks. The node weight was calculated based on the gene conservation in the 50 networks. The genes with node weight > = 5 were used for aggregation. The node size in the network plot is proportional to the node weight, and the gene symbols with the top 50 node weights are labeled. The pink node color indicates the CellAge SnGs