Fig. 6

SnG-enriched modules and associated cell types in the testis. a Sunburst plot of SnG-enriched modules in the testis. Each cell indicates a network module, and the color intensity indicates the significance of the enrichment for the CellAge SnGs (FET p-value). b The co-expression network of module M6. The CellAge SnGs in module M6 are labeled and highlighted with red color. The orange nodes are hub genes, and the node size is proportional to the connectivity in the network. c The cell-type specificity of the M6 SnGs. The marker genes for each cell type were identified by the Wilcoxon Rank Sum test from the scRNA-seq dataset. FET was performed to test the enrichment of the marker genes for the CellAge SnGs of the M6. d Volcano plot of marker gene expressions in endothelial cells. The x-axis indicates log2 transformed fold change compared with the other cell types. The y-axis indicates the statistical significance from the Wilcoxon Rank Sum test. The CellAge SnGs from M6 are labeled and highlighted in red color. e Violin plot of SnG expressions preferentially in endothelial cells (top two rows) and myoid cells (bottom two rows)