Fig. 4
From: Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients
Rapid cell death and neuroinflammation in mice injected intrathecally with a SARM1V184G AAV construct. This figure demonstrates anatomical findings from the small subset of mice with rapid onset pathology. (A) Representative images of spinal cord sections stained with DAPI and the apoptosis marker TUNEL from mice 2 days after injection with a SARM1V184G or SARM1 human reference allele construct. (B) Representative images of spinal cord stained with DAPI and the macrophage marker anti-CD68 from mice 2 days after injection with a SARM1V184G or reference allele construct. These images demonstrate that mice that become paralyzed shortly after injection with SARM1V184G exhibit cell death and activated macrophages in their spinal cords while mice injected with the control SARM1 construct do not