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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains

Fig. 5

Relationship between viral abundance and AD status. A Comparisons of HHV-6A and -6B viral abundance between AD (N = 350) and non-demented controls (N = 31) in the Knight-ADRC cohort. Diamonds in violin plot: mean of group. Shape of violin plot: distribution of normalized PathSeq scores across each group. The p-values representing the significance of difference between the viral abundance in AD and controls groups for HHV-6A and -6B are shown at the top of corresponding violin plots. The p-values were obtained by performing a non-parametric Wilcoxon Rank Sum test in order to determine if there was any relationship between viral abundance and AD classification. Abbreviations: AD, Alzheimer Disease; CO, controls; HHV, human herpes virus. B Abundance of HHV-6A and HHV-6B in Knight-ADRC. HHV-6A and HHV-6B normalized PathSeq scores displayed in an increasing order for all the samples (AD and controls) in the Knight-ADRC cohort. Normalized PathSeq score based on the number of reads that align with a references taxon and indicates the amount of evidence that a taxon is present in a particular individual

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Molecular Neurodegeneration

ISSN: 1750-1326