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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer’s disease: review, recommendation, implementation and application

Fig. 8

snATAC-Seq analysis for AD and control. A Sample 47 (AD) and sample 101 (Control) from the Swarup study are integrated and projected onto UMAP. B Cells are clustered into 11 cell clusters. Gene activity matrix is extracted from fragment file. Marker genes are then identified for each cluster and cell types are identified according to the marker genes of each cluster. C Gene activity of SLC1A2, SNAP25 and MBP are shown in AD (left) and control (right), respectively. D Accessibility and co-accessibility of SNAP25. The top panel shows normalized accessibility of 11 cell types. The two panels in the middle show the peaks around SNAP25. The bottom panel shows the co-accessibility scores among the peaks

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Molecular Neurodegeneration

ISSN: 1750-1326