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Table 5 Summary of mouse models used in single cell sequencing studies of AD

From: Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer’s disease: review, recommendation, implementation and application

Reference (PMID)

Mouse Model

Brain Region

Age (Month)

32341542

5XFAD

Prefrontal cortex

7, 10

32320664

APP/PS1 IL33 mice, APP/PS1 transgenic mice

Cerebral cortex

10–12

31932797

Trem2_KO mice, Trem2_KO_5XFAD, WT_5XFAD mice

Cortex, Hippocampus

7, 15

31928331

APP23 transgenic mice (B6. Cg-Tg (Thy1-APP)3Somm/J)

Hippocampus

6, 24

29020624

CK, CK-p25

Hippocampus

0wk,1wk, 2wk and 6wk after p25 induction into 3 m-old mouse

28602351

5XFAD

Cortex, Cerebellum

6

32503894

3XTg-AD mice

Subventricular zone and hippocampus

8

32503894

anti-Nk1.1 treated 3XTg-AD

Subventricular zone and hippocampus

7

32579671

5XFAD-CV, 5XFAD-R47H

Cortex and hippocampus

5.5

31902528

Trem2 +/+ mice, Trem2 +/− mice, Trem2 −/− mice

Hippocampus

12–14