Fig. 2
Association of selected GO biological processes and transcription factors with CSF proteins, MAGMA geneset score, and cell type. A,B GO-BP and SUZ12 and REST transcription factors enriched for proteins in AD individuals with increased t-tau (a + t +) or normal t-tau (a + t-) with increased (red) or decreased (blue) concentrations relative to controls in the total sample (A) or in the preclinical AD stage (B). P-values of all GO-BPs are listed in Data S3a. C P-value of association of GO-BP with abnormal t-tau in GWAS-based MAGMA genset analysis. P-values of all GO-BPs are listed in Data S4d. D Proportion of proteins with cell-type specific expression. A: ADNI cohort, E: EMIF-AD MBD cohort; A + t + : abnormal Aβ1-42 and increased t-tau; A + t-: abnormal Aβ1-42 and normal t-tau; CN A + t + : abnormal Aβ1-42 and increased t-tau in preclinical AD stage; CN A + t-: abnormal Aβ1-42 and normal t-tau in preclinical AD stage. Oligo = oligodendrocyte; endothelial = endothelial cell. (protein enrichment) and Data S4d (MAGMA analysis)