Fig. 2
From: Alzheimer’s disease – the journey of a healthy brain into organ failure
AD Genes and Loci associated with AD risk. AD genes are indicated in bold text whereas loci implicated by genome wide association studies (GWAS) are underlined. Y-axis indicates bidirectional risk, and the x-axis indicates the frequency of these mutations of variants. Note that several AD genes have both harmful and protective mutations or variants. For most loci implicated by GWAS, the genes and functional variants that are driving the association remain unknown. GWAS loci are derived from Kunkle et al. Nature Genetics 2019. 51(3):414–430 [32]