Fig. 9
From: Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
Pathway enrichment of proteins with Pyk2-regulated expression. A–B, Functional networks of identified proteomic hits (total protein fraction) from WT vs Pyk2−/− (A) and PS190/+ vs PS190/+;Pyk2−/− (B) analyses generated in ClueGO. Pathways involved in protein translation are boxed in red. C, Venn Diagram showing overlap of significant total protein hits between analyses. D–E, Functional networks of phospho-proteomic hits (normalized phospho-enriched fraction) from WT vs Pyk2−/− (D) and PS190/+ vs PS190/+;Pyk2−/− (E) analyses. F, Venn Diagram showing overlap of significant normalized phospho-enriched protein hits between analyses