From: Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
Fraction | Analysis | % Associated Genes | Associated Genes Found | Number of Genes | Pathway Term | GO ID | Term P-Value | Term P-Value Corrected with Bonferroni Step Down |
---|---|---|---|---|---|---|---|---|
Normalized Phospho-Enriched Protein | WT vs Pyk2−/− | 11.43 | BRSK1, GSK3A, GSK3B, MARK2 | 4 | tau-protein kinase activity | GO:0050321 | 4.49E-08 | 5.39E-07 |
2.33 | BRSK1, GSK3B, MARK2, STK11 | 4 | regulation of axonogenesis | GO:0050770 | 2.76E-05 | 2.76E-04 | ||
1.48 | AP2A1, BRSK1, GSK3A, GSK3B, MAGI2, MARK2, STK11 | 7 | regulation of neuron projection development | GO:0010975 | 3.06E-07 | 3.37E-06 | ||
1.31 | BRSK1, GSK3A, GSK3B, MARK2, STK11 | 5 | protein serine kinase activity | GO:0106310 | 3.71E-05 | 3.34E-04 | ||
1.31 | BRSK1, GSK3A, GSK3B, MARK2, STK11 | 5 | protein threonine kinase activity | GO:0106311 | 3.71E-05 | 3.34E-04 | ||
1.19 | GSK3A, GSK3B, MARK2, PLCL2 | 4 | peptidyl-serine phosphorylation | GO:0018105 | 3.62E-04 | 0.002893702 | ||
0.93 | AP2A1, BRSK1, CPNE6, GPM6B, GSK3A, GSK3B, MAGI2, MAPÂ 4, MARK2, STK11 | 10 | neuron projection development | GO:0031175 | 2.92E-08 | 3.79E-07 | ||
0.71 | BRSK1, CPNE6, GSK3B, MARK2, STK11 | 5 | neuron projection morphogenesis | GO:0048812 | 6.72E-04 | 0.004700896 | ||
0.47 | GSK3A, MAGI2, MARK2, MPP3, STK11 | 5 | positive regulation of phosphate metabolic process | GO:0045937 | 0.004069528 | 0.012208583 | ||
0.41 | BRSK1, GSK3A, GSK3B, MARK2, MPP3, PLCL2, STK11 | 7 | protein phosphorylation | GO:0006468 | 0.001289881 | 0.007739284 | ||
0.41 | GSK3A, GSK3B, MAGI2, MARK2, MPP3, PLCL2, STK11 | 7 | regulation of protein modification process | GO:0031399 | 0.001294324 | 0.006471619 | ||
0.39 | GSK3A, MARK2, MPP3, PLCL2, STK11 | 5 | regulation of protein phosphorylation | GO:0001932 | 0.008870538 | 0.017741077 | ||
0.39 | GSK3A, GSK3B, MAGI2, MARK2, MPP3, STK11 | 6 | positive regulation of cellular protein metabolic process | GO:0032270 | 0.00389758 | 0.015590322 | ||
0.36 | GSK3A, GSK3B, MARK2, MPP3, PLCL2 | 5 | peptidyl-amino acid modification | GO:0018193 | 0.011955289 | 0.011955289 | ||
PS190/+ vs PS190/+;Pyk2−/− | 1.54 | GNAO1, PTK2B, SLC30A1, TRPV2 | 4 | regulation of calcium ion transport | GO:0051924 | 4.89E-04 | 0.003424011 | |
0.89 | GRIA1, PTK2B, SCN2A, SLC30A1, TRPV2 | 5 | cation channel activity | GO:0005261 | 0.001096794 | 0.006580766 | ||
0.85 | GRIA1, PTK2B, SLC30A1, TRPV2 | 4 | cellular calcium ion homeostasis | GO:0006874 | 0.004364709 | 0.021823543 |