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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Culture shock: microglial heterogeneity, activation, and disrupted single-cell microglial networks in vitro

Fig. 6

Causal predictive network modeling reveals potential key drivers of in vitro microglia state. a Causal genetic regulatory network of astro-plated microglia with top inferred 10 key drivers Rpl27a, Prdx1, Rpl32, Ndufs5, Uqcr10, Ptpn18, Arhgap17, C1qc, Sumo2, Arhgap30) enclosed in diamonds and (b) Subnetwork of a showing downstream effector genes; (c) Causal genetic regulatory network of micro-isolated microglia and (d) its subnetwork. e The top 9 (out of total 444) key drivers replicated across both microglial cohorts (astro-plated and micro-isolated microglia) ranked by prioritization score, with larger scores indicative of greater confidence in a key driver as a modulator of microglial activation

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Molecular Neurodegeneration

ISSN: 1750-1326