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Table 3 Planned or ongoing clinical trials involving tau therapeutics

From: Tauopathies: new perspectives and challenges

Drug

Mechanism of action

Disease

Phase

ClinicalTrials.gov identifier

TRx0237

Tau aggregation inhibitor

AD

III

NCT03446001

IONIS MAPTRx

Antisense oligonucleotide

Mild AD

I & II

NCT03186989

NIO752

Antisense oligonucleotide

PSP

I

NCT04539041

Fasudil

Activation of autophagy

PSP, CBD

II

NCT04734379

Rapamycin

Activation of autophagy

MCI, AD

II

NCT04629495

MCI, AD

I

NCT04200911

ACI-35.030

Tau targeted vaccines

AD

I

NCT04445831

JACI-35.054

Tau targeted vaccines

AD

II

NCT04445831

GV1001

Tau targeted vaccines

Moderate AD

II

NCT03959553

LY3303560

Passive immunotherapy

AD

II

NCT03518073

E2814

Passive immunotherapy

AD

I & II

NCT04971733

UCB0107

Passive immunotherapy

AD

II

NCT04867616

PSP

I

NCT04658199 NCT04185415

RO7105705

Passive immunotherapy

AD

II

NCT03828747

ABBV-8E12

Passive immunotherapy

AD

II

NCT03712787

Lu AF87908

Passive immunotherapy

AD

I

NCT04149860

JNJ-63733657

Passive immunotherapy

AD Cognitive Dysfunction

II

NCT04619420

LY3372689

O-GlcNAcase enzyme inhibitor

AD

II

NCT05063539

ASN51

O-GlcNAcase enzyme inhibitor

AD

I

NCT04759365

Lithium Carbonate

GSK-3β inhibitor

FTD

II

NCT02862210

MCI

IV

NCT03185208

Tolfenamic acid

CDK5 and GSK-3β inhibitor

PSP

I/II

NCT04253132

AZP2006

Increases progranulin levels, decreases tau phosphorylation

PSP

II

NCT04008355

Salsalate

Tau acetylation inhibitor

AD

I

NCT03277573

tDCS

NIBS

AD

NA

NCT04855643

rTMS

NIBS

AD MCI

NA

NCT04294888

Sodium Oligomannate Capsules

Anti-inflammation

AD

IV

NCT05058040

JNJ-40346527

Anti-inflammation

AD MCI

I

NCT04121208

VX-745

Anti-inflammation

AD

II

NCT03435861

NE3107

Anti-inflammation

AD

III

NCT04669028

Dasatinib & Quercetin

Senolytic treatment

MCI AD

I & II

NCT04785300

EOAD MCI

II

NCT04685590

AD

I & II

NCT04063124

tPBM-2.0

Transcranial Photobiomodulation

AD

II

NCT04784416

Yangxue Qingnao pills

Traditional Chinese herb

AD

II

NCT04780399

Valacyclovir

Anti-virus

AD

II

NCT03282916

  1. AD Alzheimer’s disease, CBD corticobasal degeneration, PSP progressive supranuclear palsy, MCI mild cognitive impairment, FTD frontotemporal dementia, NA Not Applicable, EOAD early-onset AD