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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Circadian clocks, cognition, and Alzheimer’s disease: synaptic mechanisms, signaling effectors, and chronotherapeutics

Fig. 2

The SCN master clock: major efferents within the CNS, and clock-gated peripheral organ systems. Black arrows denote direct synaptic targets of the SCN. Red arrows denote cortico-limbic brain regions that are under the indirect control of the SCN, either via output from the lateral septal area (LS), or via glucocorticoid (GC) release from the adrenal gland. Blue arrows denote SCN output via the hypothalamic pituitary axis (HPA) and the autonomic nervous system (ANS) that gates the inherent oscillatory capacity of peripheral organs. The brown arrow denotes the direct, monosynaptic, input to the SCN from the retina. sPVZ: subparaventricular zone; PVNT: paraventricular nucleus of the thalamus; BNST: bed nuclei of the stria terminalis; OVLT: organ vascular of lamina terminalis; POA: preoptic area; PVN: paraventricular nucleus; DMN: dorso-medial nucleus; Hipp: hippocampus; CTX: cortex

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Molecular Neurodegeneration

ISSN: 1750-1326