Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination

Zirngibl, Martin; Assinck, Peggy; Sizov, Anastasia; Caprariello, Andrew V.; Plemel, Jason R.

doi:10.1186/s13024-022-00538-8

Molecular Neurodegeneration

Table 1 List of cytokine and chemokine transgenic mouse lines used in the cuprizone model

From: Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination

Cytokine/Chemokine	Demyelination	Oligodendrocyte death	Microgliosis	Astrogliosis	Citation
Conditional Overexpression (OE)
CNS injected lentiviral expressed – Oncostatin M (OSM)	Less	Decreased	Decreased	Decreased	[227]
GFAP expressed- C3a	More		More	More	[218]
GFAP expressed – C5a	More		More	More	[218]
GFAP expressed – IL-6	less severe after 5, reduced removal of degraded MBP	no difference	less severe	less severe	[176]
GFAP expressed – IL-6	less severe 6 and 12 weeks in lateral cerebellar nuclei; CC not assessed	less severe at 12 weeks	induces specific activation state		[177]
GFAP- expressed Platelet-derived growth factor (PDGF)-α	Normal				[228]
GFAP expressed – sCrry	Less		Less		[208]
GFAP expressed – IL-17A	more severe at 3 weeks		more severe		[229]
GFAP conditionally expressed – IFN-γ	Normal	Normal			[230]
GFAP conditionally expressed – IFN-γ PKR-like ER kinase (PERK) + /–	Normal				[231]
MBP expressed -I FN-γ	Less	Less	Less	Less	[232]
Conditional knockout (cKO)
CX3CR1 cKO – CSF1R			reduced at 5 weeks			[233]
Constitutive knockout
CCL2/3–/–	Less only in cortex, not CC	Less in cortex	Unaltered	Decreased in cortex	[234]
CCL3–/–			Unaltered		[186]
CCL3–/–	Delayed		Delayed	Delayed	[223]
CCR2–/–	Unaltered	Unaltered			[235]
CCR2–/–			Normal microgliosis but reduced macrophage infiltration		[236]
CX3CR1–/– express GFP within locus			unchanged	Reduced expression of proinflammatory cytokines	[75]
CX3CR1–/–	Decreased	Unaltered	Decreased		[235]
CXCL10–/–	Decreased	Decreased	Decreased		[186]
CXCR2–/–	Normal	Normal	Normal	Normal	[237]
CXCR2–/–	Less	Less			[238]
CXCR3–/–	no difference		less severe	less severe	[239]
IFN-β–/–	Less severe	More	diminished		[240]
IFN-a-Receptor–/–	Normal	Normal	Normal	Normal	[241]
IFN-γ-Receptor–/–	Less	Normal	Delayed		[242]
IL-17–/–	Less		Less		[243]
IL-17-Receptor–/–	Less		Less		[243]
IL-18–/–	Delayed	Delayed	Delayed	Delayed	[244]
IL-1ß–/–	Normal	Normal	Normal	Normal	[244, 245]
Interferon regulatory factor-8 (IRF-8)–/–	Less	Less	Delayed		[246]
LIF–/–	More	More			[247]
Ltα–/–	Delayed	Delayed	Delayed	Normal	[56]
Ltß-Receptor–/–	Delayed		Delayed		[248]
OSM-Receptor–/–	More	Increased			[227]
p75 neurotrophin receptor (p75NTR)–/–	Normal	Normal			[249]
TNFα–/–	Normal	Delayed	Normal		[224]
TNFα-Receptor1–/–	Normal				[224]
TNFα-Receptor2–/–	Normal				[224]
TNF-like weak inducer of apoptosis (TWEAK)–/–	Delayed	Less	Delayed	Normal	[250]
PDGF-α-Receptor + /–	Normal				[251]

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ISSN: 1750-1326

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