Skip to main content
Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target

Fig. 2

TREM2 promotes the microglial transition to DAM. TREM2 binds to NAMPs and then triggers the microglial transition to DAM (CD11c +). In mouse models, microglia deficient in either Trem2 or ApoE failed to convert to DAM. Pro-inflammatory and anti-inflammatory phenotypes have been identified in DAM. Pro-inflammatory DAM was characterized by surface marker CD44, while anti-inflammatory DAM expressed surface marker CXCR4. Both of these phenotypes occur downstream of Trem2, while the presence of pro-inflammatory DAM also requires the expression of Treml2

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326