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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Imaging tau pathology in Alzheimer’s disease with positron emission tomography: lessons learned from imaging-neuropathology validation studies

Fig. 1

Next-generation tau tracer binding to human postmortem brain tissue. A Representative sections derived from the medial temporal lobe (MTL) and frontal cortex (FC; Brodmann area 9) showing increased [3H]MK-6240 binding, which was most abundant in cortical layer V during early Braak stages III/IV; additional binding to cortical layer III was observed in tissue from AD cases (Braak stage VI). B/C Specific [3H]MK-6240 and [3H]PI-2620 binding to directly adjacent tissue sections from a cohort of 24 cases (Braak 0/I: n = 7; Braak III: n = 5; Braak IV: n = 5; Braak VI: n = 7) showing pronounced increase in tracer binding with advancing Braak stage. A previously published protocol was used for the autoradiography experiments [7]. Abbreviations: HP: Hippocampus; EC: Entorhinal cortex; PHC: Parahippocampal cortex. *p < 0.05

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Molecular Neurodegeneration

ISSN: 1750-1326