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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

Fig. 6

Elevated TSPO- and FDG-PET cortical signals in AppSAA mice. a-b Axial slices upon an MRI template show TSPO-PET and FDG-PET uptake patterns of WT and AppSAA mice at different age groups. c AppSAA KI/KI mice had a significantly higher TSPO-PET signal at 12 months and 20 months of age when compared to AppSAA +/+ control mice. d AppSAA KI/KI mice had a significantly higher glucose uptake at 12 and 20 months of age when compared to AppSAA +/+ control mice. P values: t-test; *P < 0.05, **P < 0.01, and ****P < 0.0001.

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Molecular Neurodegeneration

ISSN: 1750-1326