Fig. 7
Hyperactivity phenotype in AppSAA KI/KI mice. a-c Spontaneous activity was monitored in home-cage using running wheels. The average time running is represented for males (a) and females (b) at 4, 8, 12 and 18 months of age for the three genotypes (AppSAA +/+, KI/+ and KI/KI). Graphs are box and whisker plots. P values: one-way ANOVA with Dunnett’s multiple comparison test. AppSAA KI/KI compared to the AppSAA +/+ control group; ***P < 0.001 and ****P < 0.0001. c Illustration of time spent running averaged per genotype in female mice at 18 months of age. Data are represented as mean ± SEM. d 16–17-month-old male and female AppSAA mice (KI/KI) and wildtype littermate controls (+/+) were tested in the open field for 5 min twice a day for two days (Day 1–2; Trials 1–4) and retested two weeks later (Day 15–16; Trials 5–8). Top: Distance travelled (cm) in the center and periphery of a circular arena. Bottom: P values for the repeated three-way ANOVA with genotype (KI/KI vs +/+), sex (male vs female), and location (center vs periphery) as fixed factors and their interactions. Bars represent mean ± SEM. Number of mice indicated in parentheses