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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4

Fig. 5

p38-MAPK levels are greater in the frontal cortex of persons with AD dementia with APOE3/E4 compared with APOE3/E3. The frozen inferior frontal lobe tissue from persons with NCI or AD dementia with different APOE genotypes was homogenized to test phosphorylated p38 (p-p38) and total p38-MAPK protein levels using WB. A p-p38 and p38 protein levels in the cortex from persons with NCI (n = 6 for E3/E3; n = 6 for E3/4). B p-p38 and p38 protein levels in the cortex from persons with AD dementia (n = 6 for E3/E3; n = 8 for E3/E4). NCI, no cognitive impairment; AD, Alzheimer’s disease. WB: Western Blot. Data are represented as mean ± SEM and analyzed by Student’s t-test (two-tailed). *p < 0.05

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Molecular Neurodegeneration

ISSN: 1750-1326