Fig. 6

LTB4 levels are greater in the frontal cortex of persons with AD dementia in APOE3/E4 carriers compared to APOE3/E3 carriers. The frozen inferior frontal lobe tissue from persons with NCI or AD dementia with different APOE genotypes was homogenized and the supernatant was collected to measure the LTB4 (A, C) and PGE2 levels (B, D). (n = 12 for NCI E3/E3; n = 10 for NCI E3/E4; n = 12 for AD E3/E3; n = 10 for AD E3/E4). E 5-Lipoxygenase and Cox-2 protein levels in the RIPA homogenates of inferior frontal cortex from persons with AD dementia were detected by western blot. (n = 6 for E3/E3; n = 7 for E3/E4). NCI, no cognitive impairment; AD, Alzheimer’s disease; LTB4: leukotriene B4, PGE2: Prostaglandin E2; Cox-2: cyclooxygenase. Data are represented as mean ± SEM and analyzed by Student’s t-test (two-tailed). **p < 0.01