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Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4

Fig. 7

Selected inflammatory mediators do not differ by APOE genotype in primary astrocytes, mouse, and human cortex. A mRNA levels of some of the proinflammatory markers in primary astrocyte from ApoE3-TR or ApoE4-TR mice (n = 3 for each genotype). B mRNA levels of some of the proinflammatory cytokines in cortex of ApoE3-TR or ApoE4-TR mice. C GFAP, and Iba-1 expression in cortex of ApoE3-TR or ApoE4-TR mice. (n = 5, 3 males and 2 females for B and C). D mRNA levels of some of the proinflammatory markers in inferior frontal cortex from persons with AD dementia (n = 11 for E3/E3; n = 10 for E3/E4). E GFAP and Iba-1 expression in inferior frontal cortex from persons with AD dementia (n = 6 for E3/E3, n = 7 for E3/E4). AD, Alzheimer’s disease. Data are represented as mean ± SEM and analyzed by Student’s t-test (two-tailed). *p < 0.05

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Molecular Neurodegeneration

ISSN: 1750-1326