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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: 17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease are associated with LRRC37A/2 expression in astrocytes

Fig. 1

H1 sub-haplotypes within the MAPT 17q21.21 inversion region are associated with Parkinson’s disease risk. A. Structure of the 17q21.31 locus, which confers two distinct sub-haplotypes defined by gross structural inversion; H1 and H2. Direction of gene orientation in each haplotype is indicated by arrows. Each gene or partial gene is labeled with a distinct color and connected with a crossed rectangle between H1 and H2 to aid visualization of altered gene position between haplotypes. B-C. H1 sub-haplotype block association (-log10 p-value) with PD plotted above H1 homozygote D’ LD structure and sub-haplotype blocks generated from B. Stage 1 data and C. Stage 2 data, spanning Hg19 Chr17:43,384,997–44,913,630. C. Association (-log10 p-value) of blocks calculated in Stage 2 data (blue, top), and H1.1, H1.2 and H1.3 blocks as defined in Stage 1 applied to Stage 2 data (orange, bottom). In LD plots, red indicates high D’ and blue indicates low. Black arrows indicate similar blocks generated across Stage 1 and Stage 2 data. Grey lines indicate genome wide suggestive significance p-value of 1 × 10–5

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