Skip to main content
Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: 17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease are associated with LRRC37A/2 expression in astrocytes

Fig. 2

PD-associated sub-haplotypes are associated with LRRC37A/2 expression and copy number A-C. Expression of A. LRRC37A, B. LRRC37A2 and C. MAPT in human brain tissue, measured by RNA-seq across three different cohorts, split by sub-haplotype in blocks H1.1, H1.2 and H1.3. D. Schematic of the regions of copy number variation in the 3’ distal end of the 17q21.31 locus, as defined by Boettger et al. 2012[20]. Black arrows indicate the location of dPCR probes for (left to right) beta, alpha, LRRC37A and gamma. E-G. Copy number of gamma and LRRC37A/2 regions in blocks E. H1.1, F. H1.2 and G. H1.3. H-I. Copy number of H. gamma and I. LRRC37A/2 regions between H1 and H2 homozygotes. All statistical comparisons are against the most common sub-haplotype. ns = not significant, *p < 0.05, **p < 0.01, ***p < 0.001.

Back to article page