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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: 17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease are associated with LRRC37A/2 expression in astrocytes

Fig. 4

LRRC37A/2 is expressed in astrocytes in the substantia nigra and is co-localized with α-synuclein A. Representative images from multiplex immunofluorescent staining of human control, PSP and PD substantia nigra sections with astrocyte marker GFAP, LRRC37A, α-synuclein and pathologically phosphorylated Tau (AT8). Scale bar = 100 µm, N = 4-5. B. Co-immunoprecipitation (Co-IP) of LRRC37A (top panel) with soluble α-synuclein (bottom panel) in substantia nigra from control (C), PSP and PD brain, N = 3. Whole protein lysates and IgG only controls were included for comparison

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