Microglial TYROBP/DAP12 in Alzheimer’s disease: Transduction of physiological and pathological signals across TREM2

Table 1 Microglial and myeloid cell-surface receptors associated with TYROBP

Receptors	Gene	Species	Ligands	Ref.	Implication for disease	Ref.
SIRPß1	SIRPB1	Human, mouse	Unknown	[52,53,54]	Increased expression in AD	[55]
TREM1	TREM1	Human, mouse	PGLYRP1, HMGB1, HSP70, extracellular actin	[56,57,58,59]	Septic shock, pneumonia, bacterial infectious diseases	[60,61,62]
TREM2	TREM2	Human, mouse	ApoE, Aβ oligomers, phospholipids, lipopolysaccharide	[63,64,65,66]	Nasu-Hakola disease, early-onset AD, FTD	[67,68,69]
TREM3	Trem3	Mouse	Unknown	[70]	Unknown
TREM5	CD300LB	Human, mouse	Unknown	[71]	Unknown
MDL1 (CLEC5a)	MDL1	Human, mouse	Fucose and mannose, membrane glycans, hemagglutinin protein of influenza viruses	[72,73,74]	Chronic obstructive pulmonary disease, viral infections	[74, 75]
SIGLEC-14	SIGLEC14	Human	Glycans	[76, 77]	Unknown
SIGLEC-15	SIGLEC15	Human, mouse	Glycans, tumor-associated glycan structure, CD44	[78, 79]	Osteopetrosis	[80]
SIGLEC-16	SIGLEC16	Human, mouse	Glycans	[81]	Unknown
SIGLEC-H	SiglecH	Mouse	Unknown	[82, 83]	Unknown
pDC-TREM	pDC-Trem	Mouse	Unknown	[84]	Unknown
PILRB	PILRB	Human, mouse	Sialylated O-linked sugars	[85,86,87,88]	Unknown
mCD33 (SIGLEC-3)*	Siglec3	Mouse	Glycans	[82]	Polymorphisms of human CD33 linked to AD	[89,90,91]
IREM2	CD300E	Human, mouse	Unknown	[92, 93]	Unknown
MAIR-II (LMIR2, CLM-4, DIgR1)	Cd300C2	Mouse	Unknown	[94,95,96]	Unknown

AD Alzheimer’s disease, ApoE Apolipoprotein E, Aβ Amyloid-β, CD300LB CD300 -Like Family Member B, CLEC5 C-Type Lectin Domain Containing 5A, Siglec Sialic Acid-Binding Immunoglobulin-Type Lectins, FTD Frontotemporal dementia, mCD33 Mouse CD33, MAIR-II Myeloid-associated immunoglobulin-like receptor, pDC-TREM Plasmacytoid Dendritic Cells-Triggering Receptor Expressed On Myeloid Cells, SIGLEC-14 Sialic Acid Binding Ig-Like Lectin 14, SIGLEC-15 Sialic Acid Binding Ig-Like Lectin 15, SIGLEC-16 Sialic Acid Binding Ig-Like Lectin 16, SIGLEC-H Sialic Acid Binding Ig-Like Lectin H, SIRPβ1 Signal Regulatory Protein-Β1, TREM1 Triggering Receptor Expressed On Myeloid Cells 1, TREM2 Triggering Receptor Expressed On Myeloid Cells 2, TREM3 Triggering Receptor Expressed On Myeloid Cells 3, TREM5 Triggering Receptor Expressed On Myeloid Cells 5, TYROBP Tyrosine Kinase Binding Protein, *mCD33: mouse CD33, based on the sequence similarity in the transmembrane domain with that of mouse SIGLEC-H

ISSN: 1750-1326