Fig. 1
From: APOE targeting strategy in Alzheimer’s disease: lessons learned from protective variants
Linear structural features of apoE and the amino acid differences among common and rare variants. The numbers depict amino acid residues of the protein sequence. ApoE has three structural domains: N-terminal domain (1-167), hinge domain (168-205), and C-terminal domain (206-299). The receptor-binding region in the N-terminal domain and the lipid-binding region in the C-terminal domain are marked. ApoE3-Christchurch is abbreviated as ApoE3-Ch whereas ApoE3-Jacksonville is abbreviated as ApoE3-Jac