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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity

Fig. 1

Overview of study. Brain tissue from the prefrontal cortex was acquired for 43 individuals, and TBS-soluble extracts prepared. Tissue was extensively dialyzed in BrainPhys media to remove small molecules, such as glutamate, present in the extracts. Extracts were analyzed by proteomic profiling, and 1841 proteins quantified. These extracts were used either in a neurite integrity assay and/or in an MEA-based spontaneous activity assay. Correlations were then calculated between proteins quantified via proteomics and activity in each assay

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Molecular Neurodegeneration

ISSN: 1750-1326