Skip to main content
Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity

Fig. 2

Differentially expressed proteins in the TBS-soluble AD brain proteome. A PCA plot of brain tissue samples using proteomic data. AD TBS-soluble proteomes are heterogeneous within categories, with overlap across categories. B, C Differential expression of individual proteins was analyzed between AD vs. LP-NCI (B) and AD vs. HP-NCI (C). Many more proteins were differentially expressed in the LP-NCI vs. AD comparison than in the HP-NCI vs. AD comparison. Unpaired t-test with Welch correction, two-stage step-up, dotted line at q = 0.05. D Scatter plots of top DEPs across categories. Units are normalized abundance ratios. One-way ANOVA with Dunn’s multiple comparisons test, p-values as listed. E Top hits in the REACTOME database for GSEA of analyses in B&C. Size = number of components in that gene set, ES = enrichment score, NES = normalized enrichment score

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326