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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD

Fig. 2

Behavioral analysis of young and aged mice with PBS or ɑ-syn pff injection. A Time mobile (sec) for the first 3-min bin in the open field test in young and aged mouse cohorts. B Time mobile (sec) for the first 3-min bin in the open field test in the aged mouse cohorts separated by sex. C Percentage of freezing time to the cue in the fear conditioning test. D The ratio of freezing to cue:context in the fear conditioning test. E Combined scores from three locomotor tests (wire hang, rota-rod and horizontal beam). F Each test was normalized by calculating how many standard deviations worse than age/sex-matched PBS controls. Data are mean ± SEM. One-way ANOVA with Dunnett’s post-hoc tests were used. *p < 0.05; **p < 0.01

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