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Table 3 ApoE isoform lipid interacting abilities through the lipid binding domain and the N-binding domain

From: APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

ApoE isoform

Lipid binding domain

N-binding domain

apoE4

VLDLs, LDLs [138]

Heparan and Dermatan sulfate [143]

Heparin (↓ lipid free apoE4, lipidated apoE4 [144]

apoE3

HDL [176] LDL [118]

Heparin (lipid free apoE3) [144]

apoE2

HDL [176] ↓ LDL [177]

Heparin (lipid free apoE2) [144]

  1. ↓ (low binding affinity)
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Molecular Neurodegeneration

ISSN: 1750-1326