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Table 2 Reported functional interactions of VPS10p-D receptors with canonical AD-related proteins

From: Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease

AD-RELATED PROTEINS

VPS10p-D RECEPTORS

SorLA

Sortilin

SorCS1

SorCS2

SorCS3

APP

• [95,96,97,98,99,100]

x [101, 102]

• [97, 103,104,105]

• [106,107,108]

x [101]

 

• [84]

x [101]

Amyloid β

• [109,110,111]

• [93, 104, 112]

x [113]

x [106, 108]

  

β-secretase BACE1

• [114]

• [97, 103, 105]

   

γ-secretases (PSEN1/2)

• [91, 115]

• [91]

• [91, 115]

 

• [84, 115]

APOE

• [110, 116]

• [93]

   

α-secretases (ADAM10, ADAM17)

 

• [91, 115, 117, 118]

• [91]

  
  1. • - Functional interaction
  2. x - Transcriptional changes (indirect interaction)
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Molecular Neurodegeneration

ISSN: 1750-1326