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Table 1 Electrophysiological properties of VTA DA neurons in the PN nucleus of 3-month-old mice

From: Upregulation of Ca2+-binding proteins contributes to VTA dopamine neuron survival in the early phases of Alzheimer’s disease in Tg2576 mice

Parameter

WT

Tg2576

Statistics#

Membrane Capacitance (pF)

45.95 ± 4.09 (22)

30.39 ± 2.10 (20)

p = 0.0020

Membrane Resistance (MΩ)

344.10 ± 36.64 (16)

407.8.10 ± 39.07 (14)

p = 0.2445

AP Amplitude (mV)

48.99 ± 6.04 (10)

49.54 ± 3.59 (11)

p = 0.9384

AP Rise Time (ms)

0.81 ± 0.11 (10)

1.06 ± 0.15 (11)

p = 0.2018

AP Decay Time (ms)

3.77 ± 0.31 (10)

5.45 ± 0.94 (11)

p = 0.1170

AP Width (ms)

2.01 ± 0.20 (10)

2.78 ± 0.54 (11)

p = 0.2040

Ih Current (pA)

−3.007 ± 1.382 (13)

−9.487 ± 3.979 (12)

p = 0.1564

SK Current (pA)

85.82 ± 21.08 (15)

65.35 ± 16.21 (12)

p = 0.4488

  1. Passive membrane properties, AP parameters and amplitude of Ih and SK currents (mean ± s.e.m) of VTA DA neurons located in the PN, from 3-month-old WT and Tg2465 mice. The number of analyzed neurons is shown in brackets. # Welch’s t-test (for WT vs Tg2576)