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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: TREM2 and microglia exosomes: a potential highway for pathological tau

Fig. 1

Effects of TREM2 and microglia on exosomal spread of tau. A Trem2 KO mice exhibit exacerbated spread of tau through exosomes into the dentate gyrus region of the hippocampus from the medial entorhinal cortex using AAV expression of P301L tau. B Trem2 KO and R47H mice exhibit increased neuritic plaque tau pathology in APPPS1–21 mice seeded with insoluble tau-enriched AD brain lysate (AD-tau). C tau localization shifts from from LAMP1+ vesicles to RAB7+ vesicles in Trem2 KO microglia. D Underlying questions on the role of Trem2 in endolysosomal function and proteomic profiles that may be mechanistically affecting multivesicular bodies and tau trafficking pathways

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